Affiliation:
1. Hershey Medical Center, Hershey, Pennsylvania 17033
Abstract
ABSTRACT
We tested the propensities of four carbapenems to select for resistant
Escherichia coli
,
Klebsiella pneumoniae
,
Pseudomonas aeruginosa
, and
Acinetobacter baumannii
mutants by determining the mutant prevention concentrations (MPCs) for 100 clinical strains with various ß-lactam phenotypes. Among the members of the
Enterobacteriaceae
family and
A. baumannii
strains, the MPC/MIC ratios were mostly 2 to 4. In contrast, for
P. aeruginosa
the MPC/MIC ratios were 4 to ≥16. The MPC/MIC ratios for β-lactamase-positive
K. pneumoniae
and
E. coli
isolates were much higher (range, 4 to >16 μg/ml) than those for ß-lactamase-negative strains.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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