An Optimal Diagnostic Strategy for Tuberculosis in Hospitalized HIV-Infected Patients Using GeneXpert MTB/RIF and Alere Determine TB LAM Ag-Reference-Cited by-同舟云学术

An Optimal Diagnostic Strategy for Tuberculosis in Hospitalized HIV-Infected Patients Using GeneXpert MTB/RIF and Alere Determine TB LAM Ag

Published:2020-09-22 Issue:10 Volume:58 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Esmail Aliasgar¹²,Pooran Anil¹²,Sabur Natasha F.¹³,Fadul Mohammed¹²,Brar Mantaj S.⁴,Oelofse Suzette¹²,Tomasicchio Michele¹²,Dheda Keertan¹²⁵⁶^ORCID

Affiliation:

1. Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa

2. UCT Lung Institute & South African MRC/UCT Centre for the Study of Antimicrobial Resistance, University of Cape Town, Cape Town, South Africa

3. Department of Respirology, St. Michael’s Hospital, University of Toronto, Toronto, Canada

4. Division of General Surgery, Mount Sinai Hospital, University of Toronto, Toronto, Canada

5. Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa

6. Faculty of Infectious and Tropical Diseases, Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom

Abstract

The diagnosis of tuberculosis (TB) in HIV-infected patients is challenging. Both a urinary lipoarabinomannan (LAM) test (Alere TB LAM) and GeneXpert-MTB/RIF (Xpert) are useful for the diagnosis of TB. However, how to optimally integrate Xpert and LAM tests into clinical practice algorithms remain unclear. We performed a post hoc analysis of 561 HIV-infected sputum-expectorating patients (median CD4 count of 130 cells/ml) from a previously published randomized controlled trial evaluating the LAM test in hospitalized HIV-infected patients with suspected TB.

Funder

European and Developing Countries Clinical Trials Partnership

National Research Foundation

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01032-20

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