High-level induction of gamma interferon with various mitogens in mice pretreated with Propionibacterium acnes

Author:

Okamura H,Kawaguchi K,Shoji K,Kawade Y

Abstract

Various T-cell mitogens induced high levels of circulating gamma interferon (IFN-gamma) in mice that had been pretreated with Propionibacterium acnes. Administration of lipopolysaccharide, a B-cell mitogen, to these mice also caused pronounced production of IFN-gamma in addition to IFN-alpha and IFN-beta. The enhanced induction was most marked at about 1 week after the pretreatment.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference23 articles.

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5. Corynebacterium parvum as the priming agent in the production of tumor necrotic factor in the mouse;Green I.;J. Natl. Cancer Inst.,1977

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