TCP1γ Subunit Is Indispensable for Growth and Infectivity of Leishmania donovani-Reference-Cited by-同舟云学术

TCP1γ Subunit Is Indispensable for Growth and Infectivity of Leishmania donovani

Published:2020-07-22 Issue:8 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Yadav Shailendra¹²,Kuldeep Jitendra³,Siddiqi Mohammad I.²³,Goyal Neena¹²

Affiliation:

1. Biochemistry Division, CSIR Central Drug Research Institute, Lucknow, India

2. Academy of Scientific and Innovative Research (AcSIR), New Delhi, India

3. Molecular and Structural Biology Division, CSIR-Central Drug Research Institute, Lucknow, India

Abstract

T-complex protein-1 (TCP1) is a ubiquitous group II chaperonin and is known to fold various proteins, such as actin and tubulin. In Leishmania donovani , the γ subunit of TCP1 (LdTCP1γ) has been cloned and characterized. It forms a high-molecular-weight homo-oligomeric complex that performs ATP-dependent protein folding. In the present study, we evaluated the essentiality of the LdTCP1γ gene. Gene replacement studies indicated that LdTCP1γ is essential for parasite survival.

Funder

Council of Scientific and Industrial Research, India

Department of Biotechnology, Ministry of Science and Technology, India

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00669-20

Reference81 articles.

1. Leishmaniasis: a review

2. WHO. 2019. Leishmaniasis. Fact sheet. World Health Organization, Geneva, Switzerland. https://www.who.int/en/news-room/fact-sheets/detail/leishmaniasis. Accessed 5 March 2019.

3. Recent advances in post-kala-azar dermal leishmaniasis

4. Molyneux DH, Killick-Kendrick R. 1987. Morphology, ultrastructure and life cycles, p 121–176. In Peters W, Killick-Kendrick R (ed), The leishmaniases in biology and medicine, vol 1. Academic Press, London, UK.

5. Cell Biology of Leishmania

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