External Evaluation of a Gentamicin Infant Population Pharmacokinetic Model Using Data from a National Electronic Health Record Database-Reference-Cited by-同舟云学术

External Evaluation of a Gentamicin Infant Population Pharmacokinetic Model Using Data from a National Electronic Health Record Database

Published:2018-09 Issue:9 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ge Shufan¹,Beechinor Ryan J.¹,Hornik Christoph P.²³,Standing Joseph F.⁴,Zimmerman Kanecia²³,Cohen-Wolkowiez Michael²³,Laughon Matthew M.⁵,Clark Reese⁶,Gonzalez Daniel¹

Affiliation:

1. Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

2. Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA

3. Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA

4. Inflammation, Infection, and Rheumatology Section, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom

5. Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

6. Pediatrix Medical Group, Inc., Sunrise, Florida

Abstract

Gentamicin is a common antibiotic used in neonates and infants. A recently published population pharmacokinetic (PK) model was developed using data from multiple studies, and the objective of our analyses was to evaluate the feasibility of using a national electronic health record (EHR) database for further external evaluation of this model.

Funder

HHS | National Institutes of Health

HHS | U.S. Food and Drug Administration

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00669-18

Reference19 articles.

1. Newborns and gentamicin--how much and how often?

2. The Kinetic Profile of Gentamicin in Premature Neonates