Ribosome-Mediated Attenuation of vga (A) Expression Is Shaped by the Antibiotic Resistance Specificity of Vga(A) Protein Variants-Reference-Cited by-同舟云学术

Ribosome-Mediated Attenuation of vga (A) Expression Is Shaped by the Antibiotic Resistance Specificity of Vga(A) Protein Variants

Published:2020-10-20 Issue:11 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Vimberg Vladimir¹,Cavanagh Jorunn Pauline²³,Novotna Michaela¹,Lenart Jakub¹⁴,Nguyen Thi Ngoc Bich¹,Vesela Jana¹,Pain Maria³,Koberska Marketa¹,Balikova Novotna Gabriela¹^ORCID

Affiliation:

1. Institute of Microbiology of the Czech Academy of Sciences, Vestec, Czech Republic

2. Department of Pediatrics, University Hospital of North Norway, Tromsø, Norway

3. Department of Clinical Medicine, UiT–The Arctic University of Norway, Tromsø, Norway

4. Department of Genetics and Microbiology, Faculty of Science, Charles University, Prague, Czech Republic

Abstract

Vga(A) protein variants confer different levels of resistance to lincosamides, streptogramin A, and pleuromutilins (LS A P) by displacing antibiotics from the ribosome. Here, we show that expression of vga (A) variants from Staphylococcus haemolyticus is regulated by cis -regulatory RNA in response to the LS A P antibiotics by the mechanism of ribosome-mediated attenuation. The specificity of induction depends on Vga(A)-mediated resistance rather than on the sequence of the riboregulator.

Funder

Czech Science Foundation

Grant Agency of Charles University

Ministry of Education Youth and Sports

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00666-20

Reference51 articles.

1. Regulation of antibiotic-resistance by non-coding RNAs in bacteria