Sustainable Antiviral Efficacy of Rejuvenated HIV-Specific Cytotoxic T Lymphocytes Generated from Induced Pluripotent Stem Cells-Reference-Cited by-同舟云学术

Sustainable Antiviral Efficacy of Rejuvenated HIV-Specific Cytotoxic T Lymphocytes Generated from Induced Pluripotent Stem Cells

Published:2022-03-23 Issue:6 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Miki Shoji¹,Kawai Yohei²,Nakayama-Hosoya Kaori¹,Iwabuchi Ryutaro³,Terahara Kazutaka³,Tsunetsugu-Yokota Yasuko³⁴,Koga Michiko⁵,Matano Tetsuro¹⁶⁷,Kaneko Shin²,Kawana-Tachikawa Ai¹⁶⁷^ORCID

Affiliation:

1. AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan

2. Shin Kaneko Laboratory, Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan

3. Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo, Japan

4. Department of Medical Technology, School of Human Sciences, Tokyo University of Technology, Tokyo, Japan

5. Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan

6. Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan

7. Department of AIDS Vaccine Development, Institute of Medical Science, University of Tokyo, Tokyo, Japan

Abstract

Elimination of latently HIV-infected cells is required for HIV cure. In the “kick and kill” strategy proposed for a cure to HIV, the host immune system, including HIV-specific cytotoxic T lymphocytes (CTLs), play a central role in eliminating HIV antigen-expressing cells following reactivation by latency-reversing agents (LRAs).

Funder

Japan Agency for Medical Research and Development

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.02217-21

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