Membrane Potential-Dependent Uptake of Cationic Oligoimidazolium Mediates Bacterial DNA Damage and Death-Reference-Cited by-同舟云学术

Membrane Potential-Dependent Uptake of Cationic Oligoimidazolium Mediates Bacterial DNA Damage and Death

Published:2023-05-17 Issue:5 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Yong Melvin¹,Kok Zhi Y.²³,Koh Chong H.²³,Zhong Wenbin²³,Ng Justin TY.⁴,Mu Yuguang⁴,Chan-Park Mary B.²³,Gan Yunn-Hwen¹^ORCID

Affiliation:

1. Department of Biochemistry, Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

2. School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore, Singapore

3. Centre for Antimicrobial Bioengineering, Nanyang Technological University, Singapore, Singapore

4. School of Biological Sciences, Nanyang Technological University, Singapore, Singapore

Abstract

The treatment of bacterial infections is becoming increasingly challenging with the emergence of antimicrobial resistance. Thus, the development of antimicrobials with novel mechanisms of action is much needed.

Funder

Ministry of Education Tier 3, Singapore

Ministry of Education Tier 1, Singapore

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00355-23

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