The Plasmodium Lactate/H + Transporter PfFNT Is Essential and Druggable In Vivo-Reference-Cited by-同舟云学术

The Plasmodium Lactate/H ⁺ Transporter PfFNT Is Essential and Druggable In Vivo

Published:2023-08-17 Issue:8 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Davies Heledd¹,Bergmann Bärbel²,Walloch Philipp³,Nerlich Cornelius³,Hansen Christian³,Wittlin Sergio⁴⁵,Spielmann Tobias²^ORCID,Treeck Moritz¹⁶^ORCID,Beitz Eric³^ORCID

Affiliation:

1. Signalling in Apicomplexan Parasites Laboratory, The Francis Crick Institute, London, United Kingdom

2. Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany

3. Department of Pharmaceutical and Medicinal Chemistry, Christian-Albrechts-University of Kiel, Kiel, Germany

4. Swiss Tropical and Public Health Institute, Allschwil, Switzerland

5. University of Basel, Basel, Switzerland

6. Instituto Gulbenkian de Ciência, Oeiras, Portugal

Abstract

Malaria parasites in the blood stage express a single transmembrane transport protein for the release of the glycolytic end product l -lactate/H + from the cell. This transporter is a member of the strictly microbial formate-nitrite transporter (FNT) family and a novel putative drug target.

Funder

Deutsche Forschungsgemeinschaft

Medicines for Malaria Venture

Cancer Research UK

UKRI | Medical Research Council

Wellcome Trust

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00356-23