A Glucuronoxylomannan Epitope Exhibits Serotype-Specific Accessibility and Redistributes towards the Capsule Surface during Titanization of the Fungal Pathogen Cryptococcus neoformans-Reference-Cited by-同舟云学术

A Glucuronoxylomannan Epitope Exhibits Serotype-Specific Accessibility and Redistributes towards the Capsule Surface during Titanization of the Fungal Pathogen Cryptococcus neoformans

Published:2019-04 Issue:4 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Probert Mark¹²,Zhou Xin¹²,Goodall Margaret³,Johnston Simon A.⁴⁵,Bielska Ewa¹²,Ballou Elizabeth R.¹²,May Robin C.¹²^ORCID

Affiliation:

1. Institute of Microbiology and Infection, University of Birmingham, Edgbaston, Birmingham, United Kingdom

2. School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom

3. Institute of Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham, United Kingdom

4. Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom

5. Bateson Centre, University of Sheffield, Sheffield, United Kingdom

Abstract

Disseminated infections with the fungal species Cryptococcus neoformans or, less frequently, Cryptococcus gattii are an important cause of mortality in immunocompromised individuals. Central to the virulence of both species is an elaborate polysaccharide capsule that consists predominantly of glucuronoxylomannan (GXM).

Funder

Lister Institute of Preventative Medicine

EC | FP7 | FP7 Ideas: European Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00731-18

Reference73 articles.

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