Anti-Hepatitis B Virus Activity of ORI-9020, a Novel Phosphorothioate Dinucleotide, in a Transgenic Mouse Model-Reference-Cited by-同舟云学术

Anti-Hepatitis B Virus Activity of ORI-9020, a Novel Phosphorothioate Dinucleotide, in a Transgenic Mouse Model

Published:2004-06 Issue:6 Volume:48 Page:2318-2320
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Iyer Radhakrishnan P.¹,Roland Arlene²,Jin Yi¹,Mounir Samir¹,Korba Brent²,Julander Justin G.³,Morrey John D.³

Affiliation:

1. Origenix Technologies, Inc., St. Laurent, Quebec, Canada

2. Division of Molecular Virology and Immunology, Georgetown University, Rockville, Maryland

3. Institute for Antiviral Research, Animal, Dairy, and Veterinary Sciences Department, Utah State University, Logan, Utah

Abstract

ABSTRACT ORI-9020, a novel dinucleotide, evaluated in transgenic mice expressing hepatitis B virus (HBV), significantly reduced liver HBV DNA ( P ≤ 0.001). Levels of HBeAg and HBsAg in serum and of HBcAg in liver were not affected by treatment. A minimal effective dosage was determined to be between 1.6 and 0.5 mg/kg of body weight/day, which was similar to that observed for adefovir dipivoxil.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.48.6.2318-2320.2004

Reference7 articles.

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5. Julander, J. G., R. W. Sidwell, and J. D. Morrey. 2002. Characterizing antiviral activity of adefovir dipivoxil in transgenic mice expressing hepatitis B virus. Antivir. Res.55:27-40.

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