Abstract
Regulation of hexitol catabolism was investigated in Streptococcus mutans, a cariogenic human dental plaque bacterium. Induction of hexitol catabolic enzymes and phosphoenolpyruvate:hexitol phosphotransferase and hexitol phosphate dehydrogenase activities was regulated by an inducer exclusion mechanism initiated by D-glucose and 2-deoxy-D-glucose. Kinetic analysis of the inhibitory effect of 2-deoxy-D-glucose on initial hexitol uptake illustrated that this was a noncompetitive type of inhibition. In mutant strains of S. mutans lacking phosphoenolpyruvate:glucose phosphotransferase activity, 2-deoxy-D-glucose was unable to inhibit hexitol uptake. These observations provide evidence for possible molecular mechanisms for the exclusion process.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Reference18 articles.
1. Ethanol production and alcohol dehydrogenase activity in Streptococcus mutans;Brown A. T.;Arch. Oral Biol.,1973
2. Mannitol and sorbitol catabolism in Streptococcus mutans;Brown A. T.;Arch. Oral Biol.,1973
3. Initial characterization of sucrose-6phosphate hydrolase from Streptococcus mutans and its apparent identity with intracellular invertase;Chay B. M.;Biochem. Biophys. Res. Commun.,1979
4. Carbohydrate transport in bacteria;Dills S. S.;Microbiol. Rev.,1980
5. Hanson R. S. and J. A. Phillips. 1981. Chemical composition p. 328-364. In P. Gerhardt R. G. E. Murray R. N. Costilow E. W. Nester W. A. Wood N. R. Krieg and G. B. Phillips (ed.) Manual of methods for general bacteriology. American Society for Microbiology Washington D.C.
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