Comparison of Human Immunodeficiency Virus Type 1 (HIV-1) Protease Mutations in HIV-1 Genomes Detected in Plasma and in Peripheral Blood Mononuclear Cells from Patients Receiving Combination Drug Therapy-Reference-Cited by-同舟云学术

Comparison of Human Immunodeficiency Virus Type 1 (HIV-1) Protease Mutations in HIV-1 Genomes Detected in Plasma and in Peripheral Blood Mononuclear Cells from Patients Receiving Combination Drug Therapy

Published:1999-05 Issue:5 Volume:37 Page:1595-1597
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Koch Nathalie¹,Yahi Nouara¹,Ariasi Franck²,Fantini Jacques²,Tamalet Catherine¹

Affiliation:

1. Laboratoire de Virologie, CHRU La Timone, 13005 Marseille,1 and

2. Laboratoire de Biochimie et Biologie de la Nutrition, CNRS ESA 6033, Facultédes Sciences St. Jérôme, 13013 Marseille,2 France

Abstract

ABSTRACT Detections of mutations in the protease gene of human immunodeficiency virus type 1 in plasma and peripheral blood mononuclear cells (PBMC) were sought in two matched populations of 23 individuals receiving combination drug therapy with or without protease inhibitors. In the control group (23 patients not receiving protease inhibitors), no primary resistance mutations were found. In contrast, primary resistance mutations (especially at codons M46, V82, and L90) were found in 16 of 23 patients (70%) treated with protease inhibitors. In 30% of the cases, these mutations were detected in plasma but not in PBMC.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.37.5.1595-1597.1999

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