Quantitative Imaging Analysis of the Spatial Relationship between Antiretrovirals, Reverse Transcriptase Simian-Human Immunodeficiency Virus RNA, and Fibrosis in the Spleens of Nonhuman Primates-Reference-Cited by-同舟云学术

Quantitative Imaging Analysis of the Spatial Relationship between Antiretrovirals, Reverse Transcriptase Simian-Human Immunodeficiency Virus RNA, and Fibrosis in the Spleens of Nonhuman Primates

Published:2022-08-16 Issue:8 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Devanathan Aaron S.¹^ORCID,White Nicole R.¹,Desyaterik Yury¹,De la Cruz Gabriela²,Nekorchuk Michael³,Terry Margaret³,Busman-Sahay Kathleen³,Adamson Lourdes⁴,Luciw Paul⁴,Fedoriw Yuri²,Estes Jacob D.³⁵,Rosen Elias P.¹^ORCID,Kashuba Angela D. M.¹²

Affiliation:

1. UNC Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA

2. University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA

3. Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, USA

4. University of California at Davis, Davis, California, USA

5. Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA

Abstract

Although current antiretroviral therapy (ART) has increased life expectancy, a cure for human immunodeficiency virus (HIV) remains elusive due to the persistence of the virus in tissue reservoirs. In the present study, we sought to elucidate the relationship between antiretrovirals (ARVs) and viral expression in the spleen.

Funder

HHS | National Institutes of Health

North Carolina Biotechnology Center

Bill and Melinda Gates Foundation

American Foundation for Pharmaceutical Education

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00609-22

Reference50 articles.