HIV-2 Drug Resistance Genotyping from Dried Blood Spots-Reference-Cited by-同舟云学术

HIV-2 Drug Resistance Genotyping from Dried Blood Spots

Published:2020-12-17 Issue:1 Volume:59 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Raugi Dana N.¹^ORCID,Nixon Robert S.¹,Leong Sally¹,Faye Khadim²,Diatta Jean Phillipe³,Sall Fatima²,Smith Robert A.¹,Sall ElHadji Ibrahima³,Malomar Jean Jacques³,Seydi Moussa²,Gottlieb Geoffrey S.¹⁴

Affiliation:

1. Center for Emerging and Re-Emerging Infectious Diseases, Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA

2. Service des Maladies Infectieuses et Tropicales, Ibrahima Diop Mar, Centre Hospitalier National Universitaire de Fann, Universite Cheikh Anta Diop de Dakar, Dakar, Senegal

3. Centre de Sante de Ziguinchor, Ziguinchor, Senegal

4. Department of Global Health, University of Washington, Seattle, Washington, USA

Abstract

The treatment of HIV-2 in resource-limited settings (RLS) is complicated by the limited availability of HIV-2-active antiretroviral drugs and inadequate access to HIV-2 viral load and drug resistance testing. Dried blood spots (DBS)-based drug resistance testing, widely studied for HIV-1, has not been reported for HIV-2 and could present an opportunity to improve care for HIV-2-infected individuals. We selected 150 DBS specimens from ongoing studies of antiretroviral therapy (ART) for HIV-2 infection in Senegal and subjected them to genotypic drug resistance testing.

Funder

HHS | National Institutes of Health

AIDS Clinical Trials Group

UW | Center for AIDS Research, University of Washington

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.02303-20

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