Affiliation:
1. Clinical Immunology Research Centre, University of Sydney, Australia.
Abstract
The effect of mycobacterial phenolic glycolipids from Mycobacterium leprae, M. bovis BCG, and M. kansasii on in vitro proliferative responses by human blood mononuclear cells from healthy BCG vaccinees was investigated. All three phenolic glycolipids inhibited proliferation in a concentration-dependent manner. Inhibition was independent of the stimulus used and involved neither antigen-presenting cells nor antigen-specific CD8+ suppressor T cells. It was concluded that the phenomenon may be a general property of mycobacterial phenolic glycolipids, perhaps analogous to the growth-modulating properties of gangliosides. Despite the lack of specificity of inhibition in vitro, de facto specificity may occur in vivo by virtue of the localization of glycolipid in the leprosy lesions.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference32 articles.
1. High dose suppression of human anti influenza A virus responses using T cell clones;Adams E.;Immunol. Cell. Biol.,1987
2. Use of phenolic glycolipid I for serodiagnosis in a high prevalence village in Papua New;Baumgart K.;Guinea. Trans. R. Soc. Trop. Med. Hyg.,1987
3. Binferd C. H. and D. H. Connor (ed.). 1976. Pathology of tropical and extraordinary diseases vol. 1. Armed Forces Institute of Pathology Washington D.C.
4. Immunological unresponsiveness in leprosy;Bloom B. R.;Immunol. Rev.,1984
5. Brennan P. J. 1988. Mycobacterium and other actinomycetes p. 203-298. In C. Ratledge and S. G. Wilkinson (ed.) Microbial lipids vol. 1. Academic Press Inc. (London) Ltd. London. Editors London.
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