Inhibition of Class D β-Lactamases by Acyl Phosphates and Phosphonates-Reference-Cited by-同舟云学术

Inhibition of Class D β-Lactamases by Acyl Phosphates and Phosphonates

Published:2005-10 Issue:10 Volume:49 Page:4410-4412
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Adediran S. A.¹,Nukaga Michiyoshi²,Baurin Stéphane³,Frère J.-M.³,Pratt R. F.¹

Affiliation:

1. Department of Chemistry, Wesleyan University, Middletown, Connecticut 06459

2. Faculty of Pharmaceutical Sciences, Jyosai International University, 1 Gumyo, Togane-shi, Chiba 283-8555, Japan

3. Centre d'Ingeniere des Proteines et Laboratoire d'Enzymologie, Université de Liège, B-4000 Sart Tilman, Liège 1, Belgium

Abstract

ABSTRACT The susceptibility of typical class D β-lactamases to inhibition by acyl phosph(on)ates has been determined. To a large degree, these class D enzymes behaved very similarly to the class A TEM β-lactamase towards these reagents. Dibenzoyl phosphate stood out in both cases as a lead compound towards a new class of effective inhibitors.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.49.10.4410-4412.2005

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4. Kaur, K., S. A. Adediran, M. J. K. Lan, and R. F. Pratt. 2003. Inhibition of β-lactamases by monocyclic acyl phosph(on)ates. Biochemistry42:1529-1536.

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