Antichagasic Activity of Komaroviquinone Is Due to Generation of Reactive Oxygen Species Catalyzed by Trypanosoma cruzi Old Yellow Enzyme-Reference-Cited by-同舟云学术

Antichagasic Activity of Komaroviquinone Is Due to Generation of Reactive Oxygen Species Catalyzed by Trypanosoma cruzi Old Yellow Enzyme

Published:2005-12 Issue:12 Volume:49 Page:5123-5126
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Uchiyama Nahoko¹²,Kabututu Zakayi³,Kubata Bruno K.⁴,Kiuchi Fumiyuki⁵,Ito Michiho¹,Nakajima-Shimada Junko⁶,Aoki Takashi⁶,Ohkubo Kei⁷,Fukuzumi Shunichi⁷,Martin Samuel K.⁴,Honda Gisho¹,Urade Yoshihiro³

Affiliation:

1. Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan

2. Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyoto 610-0395, Japan

3. Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka 565-0874, Japan

4. United States Army Medical Research Unit-Kenya, Unit 64109, APO AE 09831-64109, Kenya

5. Tsukuba Medicinal Plant Research Station, National Institute of Health Sciences, Tsukuba 305-0843, Japan

6. Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, Tokyo 113-8421, Japan

7. Department of Material and Life Science, Graduate School of Engineering, Osaka University, SORST, JST, Osaka 565-0871, Japan

Abstract

ABSTRACT A novel potent trypanocidal diterpene, komaroviquinone, was reduced by Trypanosoma cruzi old yellow enzyme (TcOYE) to its semiquinone radical. The reductase activity in trypanosome lysates was completely immunoabsorbed by anti-TcOYE antibody. Since TcOYE is expressed throughout the T. cruzi life cycle, komaroviquinone is an interesting candidate for developing new antichagasic drugs.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.49.12.5123-5126.2005

Reference21 articles.

1. Araya, J. E., I. Neira, S. da Silva, R. A. Mortara, P. Manque, E. Cordero, H. Sagua, A. Loyola, J. Borquez, G. Morales, and J. Gonzalez. 2003. Diterpenoids from Azorella compacta (Umbelliferae) active on Trypanosoma cruzi. Mem. Inst. Oswaldo Cruz98:413-418.

2. del Olmo, E., M. G. Armas, J. L. Lopez-Perez, G. Ruiz, F. Vargas, A. Gimenez, E. Deharo, and A. San Feliciano. 2001. Anti-Trypanosoma activity of some natural stilbenoids and synthetic related heterocyclic compounds. Bioorg. Med. Chem. Lett.11:2755-2757.

3. Docampo, R., J. N. Lopes, F. S. Cruz, and W. Souza. 1977. Trypanosoma cruzi: ultrastructural and metabolic alterations of epimastigotes by beta-lapachone. Exp. Parasitol.42:142-149.

4. Docampo, R., F. S. Cruz, A. Boveris, R. P. Muniz, and D. M. Esquivel. 1978. Lipid peroxidation and the generation of free radicals, superoxide anion, and hydrogen peroxide in beta-lapachone-treated Trypanosoma cruzi epimastigotes. Arch. Biochem. Biophys.186:292-297.

5. Free Radical Metabolites in the Mode of Action of Chemotherapeutic Agents and Phagocytic Cells on Trypanosoma cruzi

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