Interaction of Bismuth Subsalicylate with Fruit Juices, Ascorbic Acid, and Thiol-Containing Substrates To Produce Soluble Bismuth Products Active against Clostridium difficile-Reference-Cited by-同舟云学术

Interaction of Bismuth Subsalicylate with Fruit Juices, Ascorbic Acid, and Thiol-Containing Substrates To Produce Soluble Bismuth Products Active against Clostridium difficile

Published:2005-01 Issue:1 Volume:49 Page:431-433
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Mahony D. E.¹,Woods A.¹,Eelman M. D.²,Burford N.²,Veldhuyzen van Zanten S. J. O.³

Affiliation:

1. Departments of Microbiology and Immunology

2. Chemistry

3. Medicine, Dalhousie University, Halifax, Nova Scotia, Canada

Abstract

ABSTRACT Bismuth subsalicylate (BSS), the active ingredient of Pepto-Bismol, has been used for many years to treat various disorders of the gastrointestinal tract. Using mass spectrometry and the agar dilution method, we determined that insoluble BSS interacts with certain dietary components and organic substrates to produce water-soluble products with activity against Clostridium difficile .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.49.1.431-433.2005

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