mmpL7 Gene of Mycobacterium tuberculosis Is Responsible for Isoniazid Efflux in Mycobacterium smegmatis-Reference-Cited by-同舟云学术

mmpL7 Gene of Mycobacterium tuberculosis Is Responsible for Isoniazid Efflux in Mycobacterium smegmatis

Published:2005-11 Issue:11 Volume:49 Page:4775-4777
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Pasca Maria R.¹,Guglierame Paola¹,De Rossi Edda¹,Zara Francesca²,Riccardi Giovanna¹

Affiliation:

1. Dipartimento di Genetica e Microbiologia

2. Dipartimento di Scienze Morfologiche, Eidologiche e Cliniche, University of Pavia, Pavia, Italy

Abstract

ABSTRACT The Mycobacterium tuberculosis mmpL7 gene, encoding a hypothetical resistance nodulation division transporter, confers a high resistance level to isoniazid when overexpressed in Mycobacterium smegmatis . The resistance level decreased in the presence of the efflux pump inhibitors reserpine and CCCP (carbonyl cyanide m -chlorophenylhydrazone). Energy-dependent efflux of isoniazid from M. smegmatis cells expressing the mmpL7 gene was observed.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.49.11.4775-4777.2005

Reference14 articles.

1. Banerjee, A., E. Dubnau, A. Quemard, V. Balasubramanian, K. S. Um, T. Wilson, D. Collins, G. de Lisle, and W. R. Jacobs, Jr. 1994. inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis.Science263:227-230.

2. Brennan, P. J. 2003. Structure, function, and biogenesis of the cell wall of Mycobacterium tuberculosis.Tuberculosis83:91-97.

3. Camacho, L. R., P. Constant, C. Raynaud, M. A. Laneelle, J. A. Triccas, B. Gicquel, M. Daffe, and C. Guilhot. 2001. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem.276:19845-19854.

4. Choudhuri, B. S., S. Sen, and P. Chakrabarti. 1999. Isoniazid accumulation in Mycobacterium smegmatis is modulated by proton motive force-driven and ATP-dependent extrusion systems. Biochem. Biophys. Res. Commun.256:682-684.

5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

Cited by 112 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Loss of glycerol catabolism confers carbon-source-dependent artemisinin resistance in Mycobacterium tuberculosis;Antimicrobial Agents and Chemotherapy;2024-08-28

2. α-Aminooxyacetic acid derivatives acting as pro-drugs againstMycobacterium tuberculosis;2024-04-04

3. Overexpression of a membrane transport system MSMEG_1381 and MSMEG_1382 confers multidrug resistance in Mycobacterium smegmatis;Microbial Pathogenesis;2023-12

4. Increased expression of Mycobacterium tuberculosis Rv3737 gene associated with low-level amikacin resistance;Journal of Infection and Chemotherapy;2023-11

5. Effect of tellurite on growth of extensively drug resistant (XDR) Mycobacterium tuberculosis and action on mycobacterial drug efflux pump;Journal of King Saud University - Science;2023-05