Assessing the In Vitro Effectiveness of Antimicrobials against Mycoplasma mycoides subsp. mycoides Small-Colony Type To Reduce Contagious Bovine Pleuropneumonia Infection

Author:

Ayling R. D.1,Bisgaard-Frantzen S.1,March J. B.2,Godinho K.3,Nicholas R. A. J.1

Affiliation:

1. Veterinary Laboratories Agency (Weybridge), Woodham Lane, Addlestone, Surrey KT15 3NB, United Kingdom

2. Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Edinburgh EH26 0PZ, United Kingdom

3. Pfizer Limited, Sandwich, Kent CT13 9NJ, United Kingdom

Abstract

ABSTRACT In vitro minimum inhibitory concentrations were determined for 21 antimicrobials against 41 isolates of Mycoplasma mycoides subsp. mycoides small-colony type, the cause of contagious bovine pleuropneumonia. Of the antimicrobials used most widely in Africa, oxytetracycline and tilmicosin were effective, while the isolates were resistant to tylosin. These results provide a baseline for monitoring antimicrobial resistance.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference11 articles.

1. Ayling, R. D., S. E. Baker, R. A. J. Nicholas, M. L. Peek, and A. J. Simon. 2000. Comparison of in vitro activity of danofloxacin, florfenicol, oxytetracycline, spectinomycin and tilmicosin against Mycoplasma mycoides subsp. mycoides small colony type. Vet. Rec.146:243-245.

2. Bashiruddin, J. B., T. K. Taylor, and A. R. Gould. 1994. A PCR-based test for the specific identification of Mycoplasma mycoides subsp. mycoides SC. J. Vet. Diagn. Investig.6:428-434.

3. FAO Animal Production and Health. 2004. Towards sustainable CBPP control programmes for Africa p. 29. In Proceedings of the FAO-OIE-AU/IBAR-IAEA Consultative Group on Contagious Bovine Pleuropneumonia Third Meeting Rome 12-14 November 2003. Food and Agriculture Organization of the United Nations Rome Italy.

4. Hubschle, O. J. B., K. Godinho, and R. A. J. Nicholas. 2004. Danofloxacin treatment of cattle affected by CBPP. Vet. Rec.155:403.

5. Mariner J. C. and A. Catley. 2004. The dynamics of CBPP endemism and development of effective control strategies p. 76-80. In Proceedings of the FAO-OIE-AU/IBAR-IAEA Consultative Group on Contagious Bovine Pleuropneumonia Third Meeting Rome 12-14 November 2003. Food and Agriculture Organization of the United Nations Rome Italy.

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