In-House Phage Amplification Assay Is a Sound Alternative for Detecting Rifampin-Resistant Mycobacterium tuberculosis in Low-Resource Settings-Reference-Cited by-同舟云学术

In-House Phage Amplification Assay Is a Sound Alternative for Detecting Rifampin-Resistant Mycobacterium tuberculosis in Low-Resource Settings

Published:2005-01 Issue:1 Volume:49 Page:425-427
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Símboli Norberto¹,Takiff Howard²,McNerney Ruth³,López Beatriz¹,Martin Anandi⁴,Palomino Juan Carlos⁴,Barrera Lucía¹,Ritacco Viviana¹

Affiliation:

1. Instituto Nacional de Enfermedades Infecciosas, INEI-ANLIS “Carlos G. Malbrán,” Buenos Aires, Argentina

2. IVIC, Caracas, Venezuela

3. London School of Hygiene and Tropical Medicine, London, United Kingdom

4. Institute of Tropical Medicine, Antwerp, Belgium

Abstract

ABSTRACT An in-house mycobacteriophage amplification assay for detecting rifampin-resistant Mycobacterium tuberculosis showed 100% sensitivity, 97.7% specificity, and 95.2% predictive value for resistance in a test of 129 isolates from a hot spot area of multidrug-resistant M. tuberculosis . The applicability of the test was demonstrated in the routine work flow of a low-resource reference laboratory.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.49.1.425-427.2005

Reference19 articles.

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