Kinetics Study of KPC-3, a Plasmid-Encoded Class A Carbapenem-Hydrolyzing β-Lactamase-Reference-Cited by-同舟云学术

Kinetics Study of KPC-3, a Plasmid-Encoded Class A Carbapenem-Hydrolyzing β-Lactamase

Published:2005-11 Issue:11 Volume:49 Page:4760-4762
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Alba Jimena¹,Ishii Yoshikazu¹,Thomson Kenneth²,Moland Ellen Smith²,Yamaguchi Keizo¹

Affiliation:

1. Department of Microbiology and Infectious Diseases, Toho University School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo 1438540, Japan

2. Center for Research in Anti-Infectives and Biotechnology, Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska 68178

Abstract

ABSTRACT The kinetic activity of KPC-3, a plasmid-encoded class A carbapenemase, was studied. It hydrolyzed penicillins, cephalosporins, carbapenems, and even sulbactam. The best substrate was cephalothin ( k cat /K m = 3.48 μM −1 s −1 ). The efficiency of the enzyme was similar for imipenem and meropenem ( k cat / K m , 1.4 and 1.94 μM −1 s −1 , respectively).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.49.11.4760-4762.2005

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