The RAG-2 Inhibitory Domain Gates Accessibility of the V(D)J Recombinase to Chromatin-Reference-Cited by-同舟云学术

The RAG-2 Inhibitory Domain Gates Accessibility of the V(D)J Recombinase to Chromatin

Published:2018-08 Issue:15 Volume:38 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Ward Alyssa¹,Kumari Gita²,Sen Ranjan²,Desiderio Stephen¹

Affiliation:

1. Department of Molecular Biology and Genetics and Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

2. Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, Maryland, USA

Abstract

Accessibility of antigen receptor loci to RAG is correlated with the presence of H3K4me3, which binds to a plant homeodomain (PHD) in the RAG-2 subunit and promotes V(D)J recombination. A point mutation in the PHD, W453A, eliminates binding of H3K4me3 and impairs recombination.

Funder

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute on Aging

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00159-18

Reference45 articles.

1. Modernizing the Nonhomologous End-Joining Repertoire: Alternative and Classical NHEJ Share the Stage

2. V(D)J Recombination: RAG Proteins, Repair Factors, and Regulation