Importance of a Hydrophobic Pocket for Peptide Binding in Lactococcal OppA-Reference-Cited by-同舟云学术

Importance of a Hydrophobic Pocket for Peptide Binding in Lactococcal OppA

Published:2011-08-15 Issue:16 Volume:193 Page:4254-4256
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Berntsson Ronnie P.-A.¹,Thunnissen Andy-Mark W. H.²,Poolman Bert¹,Slotboom Dirk-Jan¹

Affiliation:

1. Departments of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, Netherlands Proteomics Centre (NPC) & Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands

2. Biophysical Chemistry, Groningen Biomolecular Sciences and Biotechnology Institute, Netherlands Proteomics Centre (NPC) & Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands

Abstract

ABSTRACT Lactococcal oligopeptide-binding protein A (OppA) binds peptides with widely varied lengths and sequences. We previously hypothesized that a hydrophobic pocket in OppA preferentially binds a hydrophobic peptide side chain and thus determines its binding register. Two crystal structures of OppA with different nonapeptides now indeed show binding in different registers.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00447-11

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5. The binding specificity of OppA determines the selectivity of the oligopeptide ATP-binding cassette transporter;Doeven M. K.;J. Biol. Chem.,2004

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