Serological responses to papillomavirus group-specific antigens in women with neoplasia of the cervix uteri

Author:

Dillner L1,Moreno-Lopez J1,Dillner J1

Affiliation:

1. Department of Virology, Karolinska Institute, Stockholm, Sweden.

Abstract

Certain types of human papillomaviruses have been linked to the development of carcinoma of the cervix uteri. We have analyzed 114 serum specimens from women with cervical intraepithelial neoplasia (CIN) or carcinoma of the cervix uteri for the presence of serum antibodies against purified, disrupted bovine papillomavirus (BPV). The titers of immunoglobulin A (IgA) antibodies against BPV were slightly elevated (P less than 0.025) in the sera from CIN or cervical carcinoma patients compared with the titers of 139 serum specimens from sex- and age-matched healthy controls. In contrast, both the IgG and IgM serum antibody titers against BPV were significantly decreased for CIN and cervical carcinoma patients compared with those of healthy controls (P less than 0.001 and P less than 0.005, respectively). These results suggest that the difference between IgA and IgG or IgM antibodies to papillomavirus group-specific antigens may represent interesting serological parameters that could possibly be used in the epidemiologic study of women at risk for CIN.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Cited by 17 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Human Papillomavirus;Vaccines for Biodefense and Emerging and Neglected Diseases;2009

2. The Humoral Immune Response to Human Papillomavirus;The Papillomaviruses;2007

3. Antibodies against linear and conformational epitopes of human papillomavirus type 16 that independently associate with incident cervical cancer;International Journal of Cancer;2006-07-17

4. The Association of Human Papillomavirus Type 16 E6 and E7 Antibodies with Stage of Cervical Cancer;Gynecologic Oncology;1996-04

5. Seric and local antibodies against a synthetic peptide of HPV16;European Journal of Obstetrics & Gynecology and Reproductive Biology;1995-04

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