nsP4 Is a Major Determinant of Alphavirus Replicase Activity and Template Selectivity-Reference-Cited by-同舟云学术

nsP4 Is a Major Determinant of Alphavirus Replicase Activity and Template Selectivity

Published:2021-09-27 Issue:20 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Lello Laura Sandra¹,Bartholomeeusen Koen²,Wang Sainan¹,Coppens Sandra²,Fragkoudis Rennos³,Alphey Luke⁴,Ariën Kevin K.²⁵,Merits Andres¹^ORCID,Utt Age¹

Affiliation:

1. Institute of Technology, University of Tartu, Tartu, Estonia

2. Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium

3. University of Nottingham, School of Veterinary Medicine and Science, Loughborough, United Kingdom

4. The Pirbright Institute, Woking, United Kingdom

5. Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium

Abstract

A key element of every virus with an RNA genome is the RNA replicase. Understanding the principles of RNA replicase formation and functioning is therefore crucial for understanding and responding to the emergence of new viruses.

Funder

UKRI | Biotechnology and Biological Sciences Research Council

Wellcome Trust

Estonian Research Council

Research Foundation Flanders

EC | European Regional Development Fund

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00355-21

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