In Vitro Susceptibility of Pythium insidiosum Isolates to Aminoglycoside Antibiotics and Tigecycline-Reference-Cited by-同舟云学术

In Vitro Susceptibility of Pythium insidiosum Isolates to Aminoglycoside Antibiotics and Tigecycline

Published:2012-07 Issue:7 Volume:56 Page:4021-4023
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Mahl Deise Luiza¹,de Jesus Francielli Pantella Kunz²,Loreto Érico Silva¹,Zanette Régis Adriel¹,Ferreiro Laerte²,Pilotto Maiara Ben¹,Alves Sydney Hartz¹,Santurio Janio Morais¹

Affiliation:

1. Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil

2. Programa de Pós-Graduação em Ciências Veterinárias, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil

Abstract

ABSTRACT This study evaluated the in vitro activity of aminoglycoside antibiotics and tigecycline against Pythium insidiosum . The susceptibility tests were carried out using the broth microdilution method in accordance with the CLSI document M38-A2. MIC values for gentamicin, neomycin, paromomycin, and streptomycin ranged from 32 to 64 mg/liter, and the minimal fungicidal concentration (MFC) ranged from 32 to 128 mg/liter, which are incompatible with safe concentrations of these drugs in plasma in vivo . Tigecycline showed the lowest MIC (0.25 to 2 mg/liter) and MFC (1 to 8 mg/liter) range values. The in vitro susceptibility observed to tigecycline makes this drug a good option in future tests in vitro and in vivo for the management of pythiosis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00073-12

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