Frequency and Characteristics of Biological False-Positive Test Results for Syphilis Reported in Florida and New York City, USA, 2013 to 2017

Author:

Matthias James12,Klingler Ellen J.3,Schillinger Julia A.13,Keller Gayle2,Wilson Craig2,Peterman Thomas A.1

Affiliation:

1. Centers for Disease Control and Prevention, Atlanta, Georgia, USA

2. Florida Department of Health, Tallahassee, Florida, USA

3. New York City Department of Health and Mental Hygiene, New York, New York, USA

Abstract

Discordant syphilis test results, with a reactive nontreponemal test and nonreactive treponemal test are usually considered biological false-positive test results (BFPs), which can be attributed to other conditions. Syphilis surveillance laws mandate laboratory reporting of reactive syphilis tests, which include many BFPs. We describe the frequency of BFPs, titer distributions, and titer increases from reported test results in Florida and New York City (NYC).

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference32 articles.

1. CDC. 2018. National notifiable diseases surveillance system: syphilis ( Treponemal pallidum ) case definition. https://wwwn.cdc.gov/nndss/conditions/syphilis/case-definition/2018/.

2. Sexually transmitted diseases treatment guidelines, 2015;Workowski KA;MMWR Recomm Rep,2015

3. False-positive Tests for Syphilis Revisited

4. Point-Counterpoint: It Is Time To Use Treponema-Specific Antibody Screening Tests for Diagnosis of SyphilisPOINTCOUNTERPOINTSUMMARY

5. Syphilis testing algorithms using treponemal tests for initial screening: four laboratories, New York City, 2005–2006;CDC;MMWR Morb Mortal Wkly Rep,2008

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