Increased Accumulation of Squalene in Engineered Yarrowia lipolytica through Deletion of PEX10 and URE2-Reference-Cited by-同舟云学术

Increased Accumulation of Squalene in Engineered Yarrowia lipolytica through Deletion of PEX10 and URE2

Published:2021-08-11 Issue:17 Volume:87 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Wei Liu-Jing¹^ORCID,Cao Xuan¹²,Liu Jing-Jing³,Kwak Suryang³,Jin Yong-Su³,Wang Wei¹^ORCID,Hua Qiang¹⁴^ORCID

Affiliation:

1. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, People’s Republic of China

2. Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, People’s Republic of China

3. Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

4. Shanghai Collaborative Innovation Center for Biomanufacturing Technology, Shanghai, People's Republic of China

Abstract

This study demonstrated a novel strategy for increasing squalene production in Y. lipolytica . URE2, a bifunctional protein that is involved in both nitrogen catabolite repression and oxidative stress response, was identified and demonstrated correlation to squalene production.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.00481-21

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