Analysis of the Plasmid-Based <i>ts</i> Allele of <i>PA0006</i> Reveals Its Function in Regulation of Cell Morphology and Biosynthesis of Core Lipopolysaccharide in Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

Analysis of the Plasmid-Based ts Allele of PA0006 Reveals Its Function in Regulation of Cell Morphology and Biosynthesis of Core Lipopolysaccharide in Pseudomonas aeruginosa

Published:2022-07-26 Issue:14 Volume:88 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Yang Zhili¹^ORCID,Zhang Zengping¹,Zhu Jiaqi²,Ma Yunhao¹,Wang Jianxin¹,Liu Jianhua¹³^ORCID

Affiliation:

1. Systems Biology Laboratory, School of Marine Science and Technology, Zhejiang Ocean University, Zhoushan, Zhejiang, China

2. R&D Department, New Horizon Health Technology Company Ltd., Hangzhou, Zhejiang, China

3. National Engineering Research Center for Marine Aquaculture, Zhejiang Ocean University, Zhoushan, Zhejiang, China

Abstract

Microbial essential genes encode nondispensable function for cell growth and therefore are ideal targets for the development of new drugs. Essential genes are readily identified using transposon-sequencing technology at the genome scale.

Funder

Zhejiang Ocean University

Zhejiang Dongjie Biotechnological Co. Ltd., China

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/aem.00480-22

Reference58 articles.

1. How to manage Pseudomonas aeruginosa infections

2. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis

3. A decade of advances in transposon-insertion sequencing

4. General and condition-specific essential functions ofPseudomonas aeruginosa

5. Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter

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