Cold Shock Induces Chromosomal qnr in Vibrio Species and Plasmid-Mediated qnrS1 in Escherichia coli

Author:

Jang Hee-Chang12,Wang Yin1,Chen Chunhui1,Vinué Laura1,Jacoby George A.3,Hooper David C.1

Affiliation:

1. Division of Infectious Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA

2. Department of Infectious Diseases, Chonnam National University, Gwang-ju, Republic of Korea

3. Lahey Hospital and Medical Center, Burlington, Massachusetts, USA

Abstract

qnr genes are found in aquatic bacteria and were present in the bacterial community before the introduction of synthetic quinolones. Their natural functions are unknown. We evaluated expression of chromosomal qnr in Vibrio species in response to environmental stresses and DNA-damaging agents. Subinhibitory concentrations of quinolones, but not other DNA-damaging agents, increased expression of chromosomal qnr by more than five times in Vibrio parahaemolyticus , Vibrio vulnificus , and Vibrio mytili .

Funder

Chonnam National University Research Institute of Medical Sciences

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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