Author:
Cordeiro Rossana de Aguiar,Marques Francisca Jakelyne de Farias,Brilhante Raimunda Sâmia Nogueira,Rocha de Castro e Silva Kylvia,Mourão Charles Ielpo,Caetano Érica Pacheco,Fechine Maria Auxiliadora Bezerra,Ribeiro Joyce Fonteles,Castelo-Branco Débora de Souza Collares Maia,de Lima Rita Amanda Chaves,Mesquita Jacó Ricarte Lima,Monteiro Andre Jalles,Rocha Francisco Airton Castro,Rocha Marcos Fábio Gadelha,Sidrim José Júlio Costa
Abstract
ABSTRACTThis study evaluatedin vitrointeractions of antituberculosis drugs and triazoles againstHistoplasma capsulatum. Nine drug combinations, each including an antituberculosis drug (isoniazid, pyrazinamide, or ethambutol) plus a triazole (itraconazole, fluconazole, or voriconazole), were tested against both growth forms ofH. capsulatum. Stronger synergistic interactions were seen in isoniazid or pyrazinamide plus triazoles for the mold form and ethambutol plus voriconazole for the yeast-like form. Further studies should evaluate these combinationsin vivo.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
6 articles.
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