Author:
Tyrrell Kerin L.,Citron Diane M.,Warren Yumi A.,Goldstein Ellie J. C.
Abstract
ABSTRACTTD-1792 is a multivalent glycopeptide-cephalosporin heterodimer antibiotic with potent activity against Gram-positive bacteria. We tested TD-1792 against 377 anaerobes and 34 strains ofCorynebacteriumspecies. Against nearly all Gram-positive strains, TD-1792 had an MIC90of 0.25 μg/ml and was typically 3 to 7 dilutions more active than vancomycin and daptomycin.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference22 articles.
1. Prevalence of Corynebacteria in diabetic foot infections;Bessman;Diabetes Care,1992
2. Bactericidal acivity, postantibiotic effect, and frequency of resistance studies with TD-1792, abstr C11475;Blais,2007
3. Antistaphylococcal activity of TD-1792, a multivalent glycopeptide-cephalosporin antibiotic;Blais;Antimicrob. Agents Chemother,2012
4. Bacteriology of moderate-to-severe diabetic foot infections and in vitro activity of antimicrobial agents;Citron;J. Clin. Microbiol,2007
5. Methods for antimicrobial dilution and disk susceptibility testing of infrequently isolated or fastidious bacteria; approved guidelines;Clinical and Laboratory Standards Institute,2006
Cited by
27 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献