MicroRNA (miRNA)-to-miRNA Regulation of Programmed Cell Death 4 (PDCD4)-Reference-Cited by-同舟云学术

MicroRNA (miRNA)-to-miRNA Regulation of Programmed Cell Death 4 (PDCD4)

Published:2019-09-15 Issue:18 Volume:39 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Ajuyah Pamela¹,Hill Meredith²^ORCID,Ahadi Alireza²,Lu Jing²,Hutvagner Gyorgy²,Tran Nham²³

Affiliation:

1. School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia

2. School of Biomedical Engineering, Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, NSW, Australia

3. The Sydney Head and Neck Cancer Institute, Sydney Cancer Centre, Royal Prince Alfred Hospital, Sydney, NSW, Australia

Abstract

The regulation of tumor suppressor genes by microRNAs (miRNAs) is often demonstrated as a one-miRNA-to-one-target relationship. However, given the large number of miRNA sites within a 3′ untranslated region (UTR), most targets likely undergo miRNA cooperation or combinatorial action. Programmed cell death 4 (PDCD4), an important tumor suppressor, prevents neoplastic events and is commonly downregulated in cancer.

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00086-19

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