Oligophilic Bacteria as Tools To Monitor Aseptic Pharmaceutical Production Units-Reference-Cited by-同舟云学术

Oligophilic Bacteria as Tools To Monitor Aseptic Pharmaceutical Production Units

Published:2001-03 Issue:3 Volume:67 Page:1371-1374
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Nagarkar Parag P.¹,Ravetkar Satish D.¹,Watve Milind G.²

Affiliation:

1. Research Laboratory, Research Foundation, Serum Institute of India, Hadapsar,1 and

2. Department of Microbiology, Abasaheb Garware College,2 Pune, India

Abstract

ABSTRACT The bacterial loads of air, surfaces, and personnel in clean rooms are routinely monitored using a set of standard media. Bacteria that can grow on these media are a tiny fraction of the total numbers in any environment. A substantial proportion of bacteria long thought to be unculturable were recently shown to be oligophilic. Oligophile counts in clean rooms in our studies exceeded the standard plate counts by up to 2 orders of magnitude. They responded to disinfection routines in ways similar to the responses of conventional bacteria. We suggest that oligophiles are better tools than conventional bacteria for environmental monitoring in aseptic pharmaceutical production units.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.67.3.1371-1374.2001

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