Phagocytosis and Killing of Francisella tularensis by Human Polymorphonuclear Leukocytes

Author:

Löfgren Sture1,Tärnvik Arne1,Bloom Gunnar D.2,Sjöberg Wigert1

Affiliation:

1. Department of Clinical Bacteriology, University of Umeå, Umeå, Sweden

2. Division of Experimental Medicine, National Defence Research Institute, Department 4, Umeå, Sweden

Abstract

Bacteria of a wild strain of Francisella tularensis were less efficiently killed by human polymorphonuclear leukocytes than were bacteria of an attenuated strain. This finding was explained to some extent by a less efficient phagocytosis, but bacteria of the wild strain also seemed to be more resistant to killing after ingestion.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference24 articles.

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2. Isolation of mononuclear cells and granulocytes from human blood. Isolation of mononuclear cells by one centrifugation;Scand. J. Clin. Lab. Invest. Suppl.,1968

3. Temporal appearance of opsonizing antibody to Francisella tularensis: detection by a radiometabolic assay;Canonico P. G.;Infect. Immun.,1975

4. Immunodiffusion studies with Pasteurella tularensis antigen-rabbit antibody systems;Carlisle H. N.;J. Immunol.,1962

5. Infection-immunity in tularemia: specificity of cellular immunity;Claffin J. L.;Infect. Immun.,1972

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