Recombinant VP4 of Human Rhinovirus Induces Permeability in Model Membranes-Reference-Cited by-同舟云学术

Recombinant VP4 of Human Rhinovirus Induces Permeability in Model Membranes

Published:2008-04-15 Issue:8 Volume:82 Page:4169-4174
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Davis Matthew P.¹,Bottley Graham¹,Beales Lucy P.²,Killington Richard A.¹,Rowlands David J.¹,Tuthill Tobias J.¹

Affiliation:

1. Institute for Molecular and Cellular Biology, Faculty of Biological Sciences, The University of Leeds, Leeds LS2 9JT, United Kingdom

2. iQur Ltd., Faculty of Biological Sciences, The University of Leeds, Leeds LS2 9JT, United Kingdom

Abstract

ABSTRACT In common with all nonenveloped viruses, the mechanism of picornavirus membrane penetration during cell entry is poorly understood. The small, myristylated capsid protein VP4 has been implicated in this process. Here we show that recombinant VP4 of human rhinovirus 16 has the ability to associate with and induce membrane permeability in otherwise intact liposomes. This provides further evidence that VP4 plays a key role in picornavirus cell entry.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01070-07

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