Double-Carbapenem Therapy for Carbapenemase-Producing Klebsiella pneumoniae

Abstract

ABSTRACTThe limited treatment options available for carbapenemase-producingKlebsiella pneumoniae(KPC) have made it a formidable pathogen. Previously we have shown the enhanced activity of pharmacodynamically optimized doripenem against KPC. Capitalizing on KPC's increased affinity for ertapenem, we evaluated the efficacy of a combination of ertapenem and doripenem in both anin vitrochemostat and anin vivomurine thigh infection model. Overall, the combination of doripenem plus ertapenem demonstrated enhanced efficacy over either agent alone.