Gene Controlling the Uptake of Shikimic Acid by Escherichia coli

Abstract

Pittard, James (University of Melbourne, Melbourne, Australia), and B. J. Wallace . Gene controlling the uptake of shikimic acid by Escherichia coli . J. Bacteriol. 92: 1070–1075. 1966.—Mutants possessing an impaired ability to take up exogenously supplied shikimic acid were isolated. Mutants showing either a complete or partial loss of this activity were found. The mutations have been mapped on the Escherichia coli chromosome and occur in a single gene, situated near to the cluster of genes concerned with histidine biosynthesis. The uptake of dehydroshikimic acid was also affected by these mutations, suggesting a common mechanism for the uptake of these two related intermediates of aromatic biosynthesis.