A monoclonal antibody to human immunodeficiency virus type 1 which mediates cellular cytotoxicity and neutralization-Reference-Cited by-同舟云学术

A monoclonal antibody to human immunodeficiency virus type 1 which mediates cellular cytotoxicity and neutralization

Published:1990-02 Issue:2 Volume:64 Page:936-940
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Broliden P A¹,Ljunggren K¹,Hinkula J¹,Norrby E¹,Akerblom L¹,Wahren B¹

Affiliation:

1. Department of Virology, Karolinska Institute, Stockholm, Sweden.

Abstract

Monoclonal antibodies (MAbs) were raised against human immunodeficiency virus type 1 gp120. One MAb, P4/D10, was found to mediate highly efficient antibody-dependent cellular cytotoxicity and virus neutralization. The reactivity was located to a major neutralizing region (amino acids 304 to 323) on gp120. Five other MAbs with a similar epitopic reactivity did not show any antibody-dependent cellulan cytotoxicity activity but had a virus-neutralizing capacity.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.64.2.936-940.1990

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