Affiliation:
1. Department of Microbiology, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45219
Abstract
An experimental model of “chronic” diphtheria intoxication in the guinea pig was developed. Adult guinea pigs, subjected to a regimen of multiple sublethal doses of purified diphtheria toxin (total of 1.4 minimum lethal doses divided equally in four daily doses), developed a toxemia which terminated in death between 6 and 8 days. During an advanced stage of illness, de novo protein synthesis was assessed by in vivo incorporation of tritiated leucine into tissue proteins. With the exception of pancreas and skeletal muscle, protein synthesis in healthy, control and toxin-treated guinea pigs was comparable. The absence of notable impairment of protein synthesis in this experimental situation is discussed in terms of the mode of action of the diphtheria toxin and the pathophysiology of the disease.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference24 articles.
1. Action of diphtheria toxin in the guinea pig;Baseman J. B.;J. Exp. Med.,1970
2. Studies on the mode of action of diphtheria toxin. I. Protein synthesis in guinea pig tissues;Bonventre P. F.;J. Exp. Med.,1966
3. Studies on the mode of action of diphtheria toxin. II. Protein synthesis in primary heart cell cultures;Bonventre P. F.;J. Exp. Med.,1967
4. Inhibition of protein synthesis subsequent to intravenous or intramuscular challenge with diphtheria toxin;Bonventre P. F.;Infect. Immunity,1972
5. Studies on the mode of action of diphtheria toxin. III. Effect on subcellular components of protein synthesis from the tissues of intoxicated guinea pigs and rats;Bowman C. G.;J. Exp. Med.,1970
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献