Author:
Bennett A.,Bar-Zeev N.,Jere K. C.,Tate J. E.,Parashar U. D.,Nakagomi O.,Heyderman R. S.,French N.,Iturriza-Gomara M.,Cunliffe N. A.
Abstract
We evaluated quantitative real-time PCR to establish the diagnosis of rotavirus gastroenteritis in a high-disease-burden population in Malawi using enzyme immunoassay as the gold standard diagnostic test. In 146 children with acute gastroenteritis and 65 asymptomatic children, we defined a cutoff point in the threshold cycle value (26.7) that predicts rotavirus-attributable gastroenteritis in this population. These data will inform the evaluation of direct and indirect rotavirus vaccine effects in Africa.
Publisher
American Society for Microbiology
Cited by
41 articles.
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