Avatar Mice Underscore the Role of the T Cell-Dendritic Cell Crosstalk in Ebola Virus Disease and Reveal Mechanisms of Protection in Survivors-Reference-Cited by-同舟云学术

Avatar Mice Underscore the Role of the T Cell-Dendritic Cell Crosstalk in Ebola Virus Disease and Reveal Mechanisms of Protection in Survivors

Published:2022-09-28 Issue:18 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Rottstegge Monika¹²,Tipton Tom³,Oestereich Lisa¹²,Ruibal Paula⁴,Nelson Emily V.¹²,Olal Catherine¹²,Port Julia R.¹,Seibel Johan⁵,Pallasch Elisa¹,Bockholt Sabrina¹,Koundouno Fara Raymond¹⁶,Boré Joseph Akoi⁶,Rodríguez Estefanía¹²,Escudero-Pérez Beatriz¹²,Günther Stephan¹²,Carroll Miles W.³⁵,Muñoz-Fontela César¹²^ORCID

Affiliation:

1. Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany

2. German Center for Infection Research (DZIF) Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany

3. Pandemic Sciences Institute & Wellcome Centre for Human Genetics, University of Oxford, United Kingdom

4. Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

5. University Hospital Hamburg-Eppendorf, Institute for Transfusion Medicine, Hamburg, Germany

6. Laboratoire du Projet des Fièvres Hémorragiques de Guinée (PFHG), Conakry, Guinea

Abstract

The crosstalk between dendritic cells and T cells marks the transition between innate and adaptive immune responses, and it constitutes an important checkpoint in EVD. In this study, we present a mouse avatar model in which T cell and dendritic cell interactions from a specific donor can be studied during EVD.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00574-22

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