Contemporary Circulating Enterovirus D68 Strains Infect and Undergo Retrograde Axonal Transport in Spinal Motor Neurons Independent of Sialic Acid-Reference-Cited by-同舟云学术

Contemporary Circulating Enterovirus D68 Strains Infect and Undergo Retrograde Axonal Transport in Spinal Motor Neurons Independent of Sialic Acid

Published:2019-08-15 Issue:16 Volume:93 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Hixon Alison M.¹²,Clarke Penny³,Tyler Kenneth L.³⁴⁵

Affiliation:

1. Medical Scientist Training Program, University of Colorado, Aurora, Colorado, USA

2. Neuroscience Program, University of Colorado, Aurora, Colorado, USA

3. Department of Neurology, University of Colorado, Aurora, Colorado, USA

4. Department of Immunology and Microbiology, University of Colorado, Aurora, Colorado, USA

5. Division of Infectious Disease, Department of Medicine, University of Colorado, Aurora, Colorado, USA

Abstract

Enterovirus D68 (EV-D68) infections are on the rise worldwide. Since 2014, the United States has experienced biennial spikes in EV-D68-associated acute flaccid myelitis (AFM) that have left hundreds of children paralyzed. Much remains to be learned about the pathogenesis of EV-D68 in the central nervous system (CNS). Herein we investigated the mechanisms of EV-D68 CNS invasion through neuronal pathways. A better understanding of EV-D68 infection in experimental models may allow for better prevention and treatment strategies of EV-D68 CNS disease.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Neurological Disorders and Stroke

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00578-19

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