Myeloperoxidase Exerts Microbicidal Activity against Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Myeloperoxidase Exerts Microbicidal Activity against Mycobacterium tuberculosis

Published:1999-08 Issue:8 Volume:67 Page:4149-4152
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Borelli Violetta¹,Banfi Elena²,Perrotta Maria Giovanna¹,Zabucchi Giuliano¹

Affiliation:

1. Dipartimento di Fisiologia e Patologia1 and

2. Dipartimento di Scienze Biomediche,2 Università di Trieste, 34127 Trieste, Italy

Abstract

ABSTRACT We investigated the antimycobacterial role of myeloperoxidase (MPO), one of the most abundant granule proteins in human neutrophils. Our data indicate that purified MPO, in the presence of hydrogen peroxide, exerts a consistent killing activity against Mycobacterium tuberculosis H37Rv and against a clinical isolate. The activity is time and dose dependent and requires the presence of chloride ions in the assay medium.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.67.8.4149-4152.1999

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