Author:
Rinaldo C R,Isackson D W,Overall J C,Glasgow L A,Brown T T,Bistner S I,Gillespie J H,Scott F W
Abstract
Levels of interferon in adult bovine serum and in fetal bovine serum and tissues were examined during the course of transplacental bovine viral diarrhea virus infection. The cows produced circulating interferon between 2 and 9 days after viral inoculation, with mean peak levels in the serum on day 4. Interferon could be routinely detected in fetal tissues (e.g., thymus, spleen, and kidney) between days 4 and 21 after viral inoculation of the cows at 149 to 150 days of gestation (mid-second trimester) and in fetal serum from day 13 through day 21. Interferon was also detectable in the serum and tissues of fetuses from dams infected at day 95 of gestation (the beginning of the second trimester). In general, no differences were found between the ability of the adult and fetus to produce interferon. Fetal lamb kidney cells were more sensitive to the antiviral effects of bovine interferon than were fetal bovine kidney cells. The antiviral substance from the fetal and adult animals was characterized as interferon by standard criteria.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference49 articles.
1. Interferon response of the fetal rhesus monkey after viral infection;Barbosa L. H.;Proc. Soc. Exp. Biol. Med.,1974
2. Mechanism of recovery from viral infection in the chick embryo;Baron S.;Nature (London),1961
3. Role of viruses in the etiology of congenital malformations;Blattner R. J.;Prog. Med. Virol.,1973
4. Immunologic response of bovine fetus to bovine viral diarrhea virus;Braun R. K.;Am. J. Vet. Res.,1973
5. Pathogenetic studies of infection of the bovine fetus with bovine viral diarrhea virus. I. Cerebellar atrophy;Brown T. T.;Vet. Pathol.,1974
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