Effect of Lamivudine on Transmission of Human T-Cell Lymphotropic Virus Type 1 to Adult Peripheral Blood Mononuclear Cells In Vitro-Reference-Cited by-同舟云学术

Effect of Lamivudine on Transmission of Human T-Cell Lymphotropic Virus Type 1 to Adult Peripheral Blood Mononuclear Cells In Vitro

Published:2002-09 Issue:9 Volume:46 Page:3080-3083
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Balestrieri Emanuela¹,Forte Giancarlo²,Matteucci Claudia³,Mastino Antonio¹,Macchi Beatrice²⁴

Affiliation:

1. Department of Microbiological, Genetic and Molecular Science, University of Messina, Messina

2. Department of Neuroscience

3. Department of Experimental Medicine and Biochemical Science, University of Rome “Tor Vergata”

4. IRCCS S. Lucia, Rome, Italy

Abstract

ABSTRACT The effects of lamivudine (3TC) on in vitro infection of peripheral blood mononuclear cells (PBMC) from healthy donors with human T-cell lymphotropic virus type 1 (HTLV-1) were investigated. Direct measures of viral replication (viral DNA, RNA, and protein) all gave similar, very high 50% inhibitory concentrations in comparison with those previously reported for zidovudine. Nevertheless, 3TC inhibited HTLV-1-driven long-term growth of infected PBMC in vitro at concentrations (6.25 μM) which had poor or no direct antiviral effects, suggesting that another mechanism may be playing a role.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.46.9.3080-3083.2002

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