Clinical Isolates of Staphylococcus aureus with Ribosomal Mutations Conferring Resistance to Macrolides-Reference-Cited by-同舟云学术

Clinical Isolates of Staphylococcus aureus with Ribosomal Mutations Conferring Resistance to Macrolides

Published:2002-09 Issue:9 Volume:46 Page:3054-3056
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Prunier Anne-Laure¹,Malbruny Brigitte¹,Tandé Didier²,Picard Bertrand²,Leclercq Roland¹

Affiliation:

1. Service de Microbiologie, CHU Côte de Nacre, Caen

2. Service de Microbiologie, CHU Morvan, Brest, France

Abstract

ABSTRACT Six strains of Staphylococcus aureus isolated from cystic fibrosis patients after treatment with azithromycin were cross-resistant to azithromycin and erythromycin. None of the isolates contained erm or msr (A) genes, but they all carried either A2058G/U or A2059G mutations within the rrl genes, with a majority of the rRNA copies bearing the mutation. One strain displayed an additional mutation in the rplV gene, encoding the L22 ribosomal protein.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.46.9.3054-3056.2002

Reference20 articles.

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