Clinical Isolates of Staphylococcus aureus with Ribosomal Mutations Conferring Resistance to Macrolides

Author:

Prunier Anne-Laure1,Malbruny Brigitte1,Tandé Didier2,Picard Bertrand2,Leclercq Roland1

Affiliation:

1. Service de Microbiologie, CHU Côte de Nacre, Caen

2. Service de Microbiologie, CHU Morvan, Brest, France

Abstract

ABSTRACT Six strains of Staphylococcus aureus isolated from cystic fibrosis patients after treatment with azithromycin were cross-resistant to azithromycin and erythromycin. None of the isolates contained erm or msr (A) genes, but they all carried either A2058G/U or A2059G mutations within the rrl genes, with a majority of the rRNA copies bearing the mutation. One strain displayed an additional mutation in the rplV gene, encoding the L22 ribosomal protein.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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