Epigenetic Landscape of HIV-1 Infection in Primary Human Macrophage-Reference-Cited by-同舟云学术

Epigenetic Landscape of HIV-1 Infection in Primary Human Macrophage

Published:2022-04-13 Issue:7 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Lu Fang¹,Zankharia Urvi²,Vladimirova Olga¹,Yi Yanjie²,Collman Ronald G.²^ORCID,Lieberman Paul M.¹^ORCID

Affiliation:

1. The Wistar Institute, Philadelphia, Pennsylvania, USA

2. University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA

Abstract

Macrophages serve as a reservoir for long-term persistence and chronic production of HIV. We found an atypical epigenetic control of HIV in macrophages marked by heterochromatic H3K9me3 despite active viral transcription. HIV infection induced changes in macrophage nuclear morphology and epigenetic regulatory factors. These findings may identify new mechanisms to control chronic HIV expression in infected macrophages.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00162-22

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